Fig. 4: Philadelphia-like ALL gene signature in bulk and scRNAseq analyses of activated IL7RA-engrafted cells. | Nature Communications

Fig. 4: Philadelphia-like ALL gene signature in bulk and scRNAseq analyses of activated IL7RA-engrafted cells.

From: An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia

Fig. 4: Philadelphia-like ALL gene signature in bulk and scRNAseq analyses of activated IL7RA-engrafted cells.

a Scheme of sample acquisition for scRNAseq. b Transcriptome correlation t-SNE map after 10X scRNAseq. c Venn diagram of differentially expressed genes in bulk analysis of CD10+CD19+ and CD19+CD10high cells of the preleukemic mouse and leukemia sample vs BB control sample Source data are provided as a Source Data file. d Relative expression of selected genes displayed on t-SNE map. e GSEA enrichment plot of preleukemic cells, leukemic cells and CRLF2-IL7RAins over BB differentially expressed genes aligned to Ph-like vs non Ph-like ranked gene list (f) AUCell analysis for single-cell expression of Ph-like (Ph) gene set projected on t-SNE map.

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