Fig. 6: Gram-scale reaction and synthetic applications. | Nature Communications

Fig. 6: Gram-scale reaction and synthetic applications.

From: Ligand relay catalysis for cobalt-catalyzed sequential hydrosilylation and hydrohydrazidation of terminal alkynes

Fig. 6: Gram-scale reaction and synthetic applications.

a Gram-scale reaction. b Synthetic applications. Reagents and conditions: (a) KF (4.0 equiv.), KHCO3 (4.0 equiv.), H2O2 (23.0 equiv.), MeOH/THF = 1/1, 65 oC, 12 h; (b) KHCO3 (1.0 equiv.), H2O2 (18.0 equiv.), MeOH/THF = 1/1, r.t., 12 h; (c) CuCl2 (4.0 equiv.), CuI (18 mol%), KF (2.4 equiv.), THF, r.t., 12 h; (d) Pd/C (10 wt%), MeOH/THF = 4/1, r.t., 12 h; (e) i) SmI2 (3.4 equiv.), MeOH/THF = 1/1, r.t., 12 h; ii) BzCl (3.0 equiv.), Et3N (4.0 equiv.), THF, r.t., 2 h. The details can be found in the Supplementary Information.

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