Fig. 2: Stk11ec−/− mice show disorganized immune activation in vivo. | Nature Communications

Fig. 2: Stk11ec−/− mice show disorganized immune activation in vivo.

From: Endothelial cell-specific expression of serine/threonine kinase 11 modulates dendritic cell differentiation

Fig. 2

a Representative spleen, lymph node (LN) and thymus images and quantification of spleen, LN and thymus weight and cell number in WT and Stk11ec−/− mice (12-weeks-old, mixed-gender, n = 6–8 in organ weight; n = 4 in cell number count). Organ weight: †P = 0.03; *P < 0.001; #P = 0.04 versus WT; Cell number: *P < 0.001; #P = 0.008 versus WT analyzed by Student’s t-test (two-sided). b Representative images of H&E-stained (left) and CD61 (megakaryocyte marker) DAB-stained (right) spleen of WT and Stk11ec−/− mice. Quantification of spleen megakaryocytes number per low power field (per LPF, 10× field) of WT and Stk11ec−/− mice (12-weeks-old, mixed-gender, n = 7–8 each group). Scale bar: (Black) 200 μm, (White) 50 μm. *P < 0.001 versus WT analyzed by Student’s t-test (two-sided).

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