Table 2 Comparison of PF-332 exposure in plasma at sacrifice (4 days post-infection) with infectious virus titers in lungs.

From: The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern

Treatment group

Hamster ID

TCID50/mg/lung

Plasma conc (nM) at d4a

Mean plasma conc (nM) at d4a

Vehicle

1

3·104

0

0

2

7·104

0

3

2·103

0

4

7·104

0

5

9·104

0

6

105

0

PF-332 (125 mg/kg/BID)

7

2·103

94

105 ± 35

8

0

122

9

2·104

39.0

10

10

134

11

2·104

118

12

104

125

PF-332 (250 mg/kg/BID)

13

0

122

275 ± 163

14

0

142

15

0

537

16

0

401

17

0

193

18

0

255

  1. Average exposure in hamsters treated with 125 mg/kg, BID (105 ± 35 nM) is significantly lower (P < 0.05) than exposure in hamsters treated with 250 mg/kg, BID (275 ± 163 nM), unpaired Student t-test with equal distribution.
  2. aday4 is the day of sacrifice of treated hamsters.
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