Fig. 1: Cryo-EM structures of desensitized and activated GluA1/2_γ8 receptors.
From: Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor
a Periphery: simplified AMPAR gating cycle using models of closed (resting; PDB: 6QKC), open and desensitized states. Labels (values and arrows) indicate conformational changes leading to the next state along the stippled arrows (e.g. labels on the closed state reflect the changes leading to the open state, etc.). Centre: current AMPAR gating model7 where a pre-open transition state (centre) leads to either open or desensitized conformations. b Cryo-EM map of the open state; side view left, top view right. Transmembrane domain (TMD) and ligand-binding domain (LBD) layers are indicated; D1 and D2 denote upper and lower LBD lobe, respectively. Subunit labels are denoted (A–D and B′D′). c As in (b) but for the desensitized state.
