Fig. 2: CICI formation at loci with different Hi-C contact frequencies.
A Six loci pairs were chosen for the CICI test. B Hi-C signals of the six pairs of loci based on published datasets (see Methods and Supplementary Data 1 for details). Data shown are the average of two biological replicas (individual data points are also shown). C The dynamics of CICI formation for loci pairs 2–6 (from left to right). The total numbers of data points were 387 (CICI) and 764 (control) for (2), 430 and 713 for (3), 724 and 338 for (4), 5376 and 228 for (5), and 4830 and 3156 for (6). The smooth curves are exponential fitting of the data (Methods). Error bars represent standard error (same for D–G). D–G The correlation between Hi-C signal with the initial distance between the dots (D), initial co-localization probability (E), CICI efficiency (F), and the half-time of CICI formation (G). The initial distance and co-localization probability were derived from the data shown in Fig. 1E and C at t = 0 time points, and CICI efficiency and the half-time were calculated from the fitting parameters. Points represent loci pairs 6, 4, 5, 3, 1, and 2 from left to the right. The corresponding coefficients of determination R2 are shown in the panels. Source data for B–G are provided as a Source Data file.
