Fig. 3: The orthosteric LPA-binding pocket of the active LPA1. | Nature Communications

Fig. 3: The orthosteric LPA-binding pocket of the active LPA1.

From: Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate

Fig. 3: The orthosteric LPA-binding pocket of the active LPA1.

a, b Cartoon representation of LPA1 with the bound LPA in spheres, and rotated 90° to show the two binding modules of transmembrane (TM) helices indicated by dashed lines. c Slice through view of the LPA-binding pocket. d–f Residues involved in interacting with the hydrocarbon chain (d, e) or the polar head group (f) of LPA are shown in sticks.

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