Fig. 7: Interactions between ICL2 of S1P1 and Gαi. | Nature Communications

Fig. 7: Interactions between ICL2 of S1P1 and Gαi.

From: Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate

Fig. 7: Interactions between ICL2 of S1P1 and Gαi.

a L151 in ICL2 is inserted into the hydrophobic pocket at the end of the N-terminal helix of Gαi, and N153 forms hydrogen bonds with D350 and N347 from the α5 helix of Gαi. b L235 and F237 in ICL3 contact the hydrophobic surface of Gαi, and K250 forms a salt bridge with D341 from the α5 helix of Gαi. R321 located at TM5 stretches to the amino-end of TM3 helix and interacts with the carbonyl backbone through hydrogen bonding.

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