Fig. 8: The dynamic interactions between LPA1 and Gαi. | Nature Communications

Fig. 8: The dynamic interactions between LPA1 and Gαi.

From: Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate

Fig. 8: The dynamic interactions between LPA1 and Gαi.

a The superposition of State a and a’ in the first component of 3DVA with the receptor shown in white surface and Gβγ removed for clarity. b, c Key residues for the interactions among ICL2, TM4 and TM5 of the receptor and the α5 helix of Gαi are shown in sticks for comparisons overlaid with the surface view of Gαi. d, e Comparison of the side chain rotamers of F354 at the two states.

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