Fig. 3: Ab1303 and Ab1573 recognize the CD4bs of BG505 Env trimer.
a Left: epitope of Ab1303 on gp120 surface with contacts made by antibody heavy and light chains colored in dark and light green, respectively. Right: CDR loops of Ab1303 mapped onto the gp120 surface. b Highlighted interactions between gp120 residues (gray sticks) and the Ab1303 CDRH3 (green sticks). The gp120 CD4 binding loop is shown in yellow with D368gp120 residue highlighted in stick representation. c Left: epitope of Ab1573 on gp120 surface with contacts made by antibody heavy and light chains colored in dark and light teal, respectively. Right: CDR loops of Ab1573 mapped onto the gp120 surface. d Highlighted interactions between gp120 residues (gray sticks) and the Ab1573 CDRH1 and CDRH3 (teal sticks). CD4 binding loop of gp120 is shown in yellow with D368 residue shown in stick. e Left: epitope of b12 on gp120 surface with contacts made by antibody heavy and light chains colored in dark and light cyan, respectively. Right: CDR loops of b12 mapped onto the gp120 surface. f Highlighted interactions between gp120 V1V2 and the b12 VL. g Comparison of the buried surface areas (BSAs) between the antibodies and gp120.
