Fig. 4: Differences in antibody-binding poses for CD4bs bNAbs compared with CD4. | Nature Communications

Fig. 4: Differences in antibody-binding poses for CD4bs bNAbs compared with CD4.

From: Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

Fig. 4

Upper and lower left: surface representation of HIV-1 Env trimer (top) and gp120 monomer (bottom) showing locations of the threefold axis relating Env protomers (red arrow), the gp120 inner domain, V1V2, V3, and gp41. Remaining panels: Cartoon diagrams of VH-VL domains of the indicated bNAbs bound to HIV-1 gp120 (gray surface, pink spheres for N-linked glycans, V1V2 in orange, V3 in blue). PDB codes: Ab1303 and Ab1573 (this study), b12 (5VN8), CD4 (6U0L), IOMA (5T3Z), 3BNC117 (5V8M), a VRC01 derivative (6NNF), and an N6 derivative (6NM6). The V1V2 and V3 regions were largely disordered in the CD4-bound Env structure (PDB 6U0L).

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