Fig. 6: Structural changes between Env trimer states. | Nature Communications

Fig. 6: Structural changes between Env trimer states.

From: Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer

Fig. 6

a Conformations of gp120/gp41 protomers in closed (left), Ab1303/Ab1573-bound (middle), and CD4-bound (right) states. The gp120 V1V2-V3 regions and gp120 α0/gp41 HR1C regions are highlighted in dashed boxes. Positions of Gly41gp120 and Pro493gp120 are shown as red spheres. b Structural rearrangements of gp120 V1V2 and V3 regions in closed (left), Ab1303/Ab1573-bound (middle), and CD4-bound (right) states. Secondary structures and relative locations of the 3-stranded sheet (left and middle) and rearranged 4-stranded bridging sheet (right) are highlighted, and respective topology models are shown in insets. Dotted lines represent disordered regions. c Comparison of gp120 α0 and neighboring region in closed (left), Ab1303/Ab1573-bound (middle), and CD4-bound (right) structures. Residues Asp57gp120 - Glu62gp120 are teal, α0 residues (Lys65gp120 - Ala73gp120) are salmon, with the His66gp120 and Trp69gp120 side chains shown. The N-terminal segment of gp41 HR1C is dark purple.

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