Fig. 8: Accumulation of DiR-stained T cells in xenograft mice models after injection of T cells. | Nature Communications

Fig. 8: Accumulation of DiR-stained T cells in xenograft mice models after injection of T cells.

From: EBV miRNAs BART11 and BART17-3p promote immune escape through the enhancer-mediated transcription of PD-L1

Fig. 8

Nude mice were injected with tumor cells after transfection of EBV-miR-BART11 and EBV-miR-BART17-3p mimics, inhibitors, or negative control (NC). After following an observation period of 7 days, DiR-labeled activated T cells were injected through the tail vein. The PD-L1 inhibitor (Atezolizumab) was injected into mice after performing T cells injection. a Representative images of the DiR fluorescence in mice. The color scales indicate the DiR fluorescence intensity in mice. b Statistical results according to the DiR fluorescence signal ratio in mice collected at 1 hour, 1 day, 3 days and 7 days post-injection (the DiR fluorescence signal ratio, T-cell fluorescence intensity in tumors of the root of the right thigh: T-cell fluorescence intensity in the abdomen of mice). Data are presented as mean ± s.d., and p-values are calculated by unpaired two-sided t-test. Source data are provided as a Source Data file.

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