Table 1 Traditional MR results and sensitivity analyses.

From: Robust Mendelian randomization in the presence of residual population stratification, batch effects and horizontal pleiotropy

 

Traditional MR

Sensitivity PRS-outcome

Sensitivity PRS-exposure

Outcome

Risk difference (95% CI)

P value

Partial R2

RVα = 0.05

Partial R2

RVα = 0.05

DBP

0.145 (0.116–0.173)

4.2 × 10−22

0.035%

1.47%

1.67%

11.88%

Deprivation

0.033 (0.006–0.060)

0.017

0.002%

0.08%

  
  1. P-values correspond to two-sided t-tests in a two-stage least squares regression. No multiple testing corrections were performed.
  2. CI Confidence Interval, DBP Diastolic Blood Pressure, MR Mendelian Randomization, PRS Polygenic Risk Score, RV Robustness Value.
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