Table 4 Simulation in which pleiotropic pathways are concentrated on only a subset of variants.
|  | Proportion of rejections of the null (α = 5%) | Critical k | RVα=0.05 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
# of valid variants | IVW | PRESSO | Egger | GENIUS | MBE | Mix | 5th | 95th | 5th | 95th |
20 | 100% | 100% | 99% | 100% | 88% | 67% | 0 | 0.9 | 0% | 0.5% |
40 | 100% | 100% | 99% | 100% | 91% | 60% | 0 | 0.9 | 0% | 0.4% |
60 | 99% | 99% | 98% | 100% | 87% | 56% | 0 | 0.9 | 0% | 0.3% |
80 | 57% | 56% | 68% | 100% | 55% | 25% | 0 | 0.7 | 0% | 0.1% |
90 | 4.3% | 4.6% | 3.5% | 100% | 0.5% | 2.1% | 0 | 0 | 0% | 0 |
