Fig. 5: Conformational states of GluN1b-GluN2B NMDAR-Fab5 complex.
From: Development and characterization of functional antibodies targeting NMDA receptors
a 3D classes of the GluN1b-GluN2B NMDAR-Fab5 in the presence of glycine and glutamate. The four 3D classes belong to nonactive1, nonactive2-like, nonactive2, and active conformations. b–d The structures of GluN2B ATD (panel b), GluN1b-GluN2B ATD heterodimer (panel c), and GluN1b-GluN2B LBD heterodimers (panel d) from GluN1b-GluN2B NMDAR-Fab5 are compared to those of GluN1b-GluN2B NMDAR in nonactive1 (PDB code 5FXH; colored gray). e Side views of GluN1b (magenta, upper panel) and GluN2B (dark green, lower panel) showing residues around the channel gating ring (GluN1b Gln817 and GluN2B Arg682 in spheres). f Schematic presentation of interdomain and –subunit movements.
