Fig. 9: Potential mechanism of inhibition by Fv2, Fab2, or IgG2.
From: Development and characterization of functional antibodies targeting NMDA receptors
a Fv2, Fab2, and IgG2 bind to the R1 lobe of GluN2B ATD and stabilized the closed bi-lobe by two major long-range paths: one that directly goes from GluN2B ATD R1 to R2, and the other that goes from GluN2B ATD R1 to GluN1b ATD R1 and to GluN2B ATD R2 (red arrows). b The GluN2B ATD bi-lobe closure mediated by the long-range interactions shifts conformational equilibrium of the receptor toward non-active1, thereby favoring inhibition.
