Fig. 5: (Patient 6) AEC-VIZ and MI-VIZ hotspot concordance with the earliest source localisation solution (early-ESL) and resection margin.
From: Virtual intracranial EEG signals reconstructed from MEG with potential for epilepsy surgery
Despite ViEEG being defined by only MSL solutions (only MEG data was used to reconstruct ViEEG signals in this study), dynamical network models suggest AEC-VIZ and MI-VIZ hotspots are concordant with the earliest source localisation solution, which was early-ESL in this case (not early-MSL), and the second resection (magenta). However, note the more dispersed AEC-VIZ NI map that encompasses the first failed resection (purple) as well. Both hotspots are discordant with MSL (see Supplementary Fig. 10 for early-, mid- and late-MSL solutions). Overlap of AEC-VIZ and MI-VIZ boundaries is also present. Note that this patient had focal motor status epilepticus (left face and hand) and a segment of continuous epileptic discharges is modelled. The second resection (years after the first failed resection with normal histology) led to an Engel I seizure-free outcome at follow-up over 2 years (histology cortical dysplasia). Abbreviations: MEG magnetoencephalography, iEEG intracranial electroencephalography, ViEEG virtual intracranial electroencephalography, EZ epileptogenic zone, SOZ seizure onset zone, HDEEG high density electroencephalography, VIZ virtual ictogenic zone, MSL MEG source localisation, ESL HDEEG source localisation, AEC amplitude envelope correlation, MI mutual information, AEC-VIZ virtual ictogenic zone using amplitude envelope correlation, MI-VIZ virtual ictogenic zone using mutual information, NI node ictogenicity.
