Table 1 Patient information, MEG seizures, earliest source localisation solution and outcome.

From: Virtual intracranial EEG signals reconstructed from MEG with potential for epilepsy surgery

Patient

MRI

Histology

MEG seizures recorded

MEG seizures reconstructed

Earliest solution from ESL and MSL

Engel outcome

1

Normal

CD 1A

6

1

MSL

I (Rare non-disabling seizures)

2

Normal

CD 1

2

2

ESL

I (Seizure free)

3

Normal

CD 2A

7

6

MSL

I (Rare non-disabling seizures)

4

Normal

Non-specific

8

5

MSL

III (Fewer disabling seizures)

5

Normal

CD 1C

2

1

MSL

I (Seizure free)

6

Normal

CD 1

1

1

ESL

I (Seizure free)

7

Normal

CD 2A

1

1

Non-localising

I (Seizure free)

8

Normal

CD 1

2

2

ESL

I (Seizure free)

9

Normal

CD 2B

2

1

ESL

II (Rare disabling seizures)

10

Multi-lobar dysplasia

Normal

1

1

MSL

I (Non-disabling seizures)

11

Multi-lobar dysplasia

Ischaemia

2

2

MSL

III (Fewer disabling seizures)

12

Right frontal gliosis

Gliosis

2

2

ESL

I (Seizure free)

  1. Twelve patients had 36 seizures recorded by MEG. 25/36 seizures reconstructed using ViEEG present distinct morphological features of epileptiform discharges in source space. Six patients achieved seizure-freedom. Nine patients had normal MRI scans while three patients had complex lesions. Early-MSL predicted the EZ in six patients (Patients 1, 3, 4, 5, 10, 11), while early-ESL predicted the EZ in five patients (Patients 2, 6, 8, 9, 12). Ictal discharges were not localisable in one patient (Patient 7). One patient from the original 13 patients published by Plummer et al.36 with normal MRI only had interictal discharges captured by HDEEG and MEG and hence was not included in the present study.
  2. CD cortical dysplasia, HDEEG high density EEG, ESL HDEEG source localisation, MSL MEG source localisation), ViEEG virtual intracranial EEG, EZ epileptogenic zone.
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