Fig. 5: HLA polymorphism in the SABE cohort.
From: Whole-genome sequencing of 1,171 elderly admixed individuals from Brazil
SABE and 1KGP3 samples were processed with the same HLA workflow, as described in the Supplementary Information. A Average gene diversity across SABE and the 1KGP3 populations considering haplotypes of all SNVs, i.e., the 2064 SNVs from six HLA class I genes, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, and HLA-G. SABE all samples from SABA dataset, SABE-ADM samples with at least 30% of both European and African global ancestry, SABE-EUR samples with 100% European global ancestry. B The proportion of previously and newly described SABE HLA SNVs according to different minor allele frequency classes. C HLA imputation accuracy when using the 1KGP3 (blue), SABE (green), and combining both (orange). Imputation was performed on 146 highly admixed Brazilians previously genotyped on Axiom Human Origins array and HLA genotyping by sequence-based typing methods.
