Fig. 5: Fast backbone dynamics (ps–ns) of N-Mdm2 in complex with nutlin-3a. | Nature Communications

Fig. 5: Fast backbone dynamics (ps–ns) of N-Mdm2 in complex with nutlin-3a.

From: Leveraging the multivalent p53 peptide-MdmX interaction to guide the improvement of small molecule inhibitors

Fig. 5

The order parameter (a, S2) and timescale of motion (b, τe) of N-Mdm2 in complex with nutlin-3a are plotted against the backbone amide residue. The secondary structure is shown on the top of the graph. R, S, and H denote the flexible region, β-sheet, and α-helix, respectively. Regions with enhanced dynamics are shaded in gray. The data are represented as mean values ± SD and error bars for each parameter represent the propagated uncertainty determined from Monte Carlo simulations. Source data for (a, b) are provided as a Source Data file.

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