Fig. 8: Rational transformation of p53p into small-molecule inhibitors of MdmX. | Nature Communications

Fig. 8: Rational transformation of p53p into small-molecule inhibitors of MdmX.

From: Leveraging the multivalent p53 peptide-MdmX interaction to guide the improvement of small molecule inhibitors

Fig. 8

a The structure and activity relationships of p53p and nutlin analogs are compared based on Fg1 and Fg5. n = 3 independent experiments and the data are represented as mean values ± SD. Source data are provided as a Source Data file. b Molecular structures of nutlin analogs H202 and H203. c, d Structure models of N-MdmX interacting with H202 and H203, evaluated by molecular docking.

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