Fig. 8: Proposed simplified model of ADAP1-mediated T cell signaling stimulation leading to latent HIV-1 reactivation. | Nature Communications

Fig. 8: Proposed simplified model of ADAP1-mediated T cell signaling stimulation leading to latent HIV-1 reactivation.

From: ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS–ERK–AP-1 T cell signaling-transcriptional axis

Fig. 8

a In resting conditions, ADAP1 is largely localized to the cytosol, HIV-1 is in a latent state and T cell programs are quiescent. b Upon stimulation (TCR/CD28), ADAP1 is re-localized to the cell membrane where it interacts with immune signalosome proteins including PKCθ and signal transducer protein KRAS, stimulating the MAPK pathway including KRAS–ERK–AP-1 (Fos/Jun). Activated AP-1 binds cis-elements on the HIV-1 genome inducing reactivation from latency. For T cell genes, ADAP1-induced AP-1 bind cis-elements of genes required for T cell programs, including genes that require NFAT:AP-1 cooperativity.

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