Fig. 3: Inter-lesion diversity analysis of paired tumors from the same patient. | Nature Communications

Fig. 3: Inter-lesion diversity analysis of paired tumors from the same patient.

From: Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma

Fig. 3: Inter-lesion diversity analysis of paired tumors from the same patient.

a, d, g Schematic diagrams illustrate the anatomical sites and time intervals of paired tumors obtained from patients MF30 (a), MF21 (d) and MF28 (g). b, e, h UMAP plots showing all T cells from paired tumors from patients MF30 (b), MF21 (e) and MF28 (h), with cells colored by sample ID, TCR clonotypes (TCR information is shown in color and each color represents a distinct TCR clonotype) and cell types in sequence. c, f, i Pseudotime trajectory analysis of all T cells from paired tumors of patients MF30 (c), MF21 (f) and MF28 (i) inferred by Monocle 2, in which reactive T cells were selected as the start cells. Cell trajectories are further shown separately according to sample ID, with cells colored by cell types. j, k Venn diagrams show the numbers of nonsynonymous mutations of paired tumors from patient MF30 (j) and MF21 (k) inferred from WES data (left). Putative driver mutations are annotated on the phylogenetic trees of paired tumors (right). Missense mutations are in blue. Nonsense mutations are in green. Frameshift mutations are in purple. The length of each line is proportional to the number of nonsynonymous mutations. Source data for (j) and (k) are provided in the Source Data file.

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