Fig. 1: Melanoma patient samples show heterogeneous SOX10 expression.
From: Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma
a tSNE plot of scRNA-seq cells colored by SOX10 expression level from Jerby-Arnon, et al. b As in a except cells colored by treatment. c Melanoma patient samples from Thomas Jefferson Hospital stained for SOX10. Scale bars, 200 μm. d TMA samples stained for SOX10. In each sample, the percentage of cancer cells expressing none, low, medium, or high levels of SOX10 was quantified by a pathologist (Dr. Xu). Samples were sorted based on their H-score (low to high). e Immunofluorescence images of A375, cells stained for SOX10 (green), filamentous actin (red), and DAPI (blue). The experiment was performed independently twice, and representative images are shown. Scale bar, 100 μm. f As in e except MeWo cells were used. g As in e except 1205Lu cells were used.
