Fig. 5: Crystal structure of hMPV F DS-CavEs2 exhibits a prefusion conformation.
From: Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins
a Side view of the atomic model of apo hMPV F variant (DS-CavEs2) in a prefusion conformation. The model (red ribbon) is superimposed with a previously determined hMPV F structure (white ribbon, PDB ID: 5WB0). The side chains of the introduced substitutions are highlighted as sticks. Each inset corresponds to the regions where the superimposition is performed. b Representative negative stain EM 2D class averages of DS-CavEs2 complexed with MPE8 Fab.
