Fig. 2: Germline Mutation Carrier Rate in Prostate Cancer Cases. | Nature Communications

Fig. 2: Germline Mutation Carrier Rate in Prostate Cancer Cases.

From: Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes

Fig. 2: Germline Mutation Carrier Rate in Prostate Cancer Cases.

Carrier frequencies were calculated as the proportion of patients carrying at least one rare germline mutation on the DNA Damage Response Gene (DDRG). a Germline mutation carrier frequency in mutated DDR genes in African American (AA) cohort. b Germline mutation carrier frequency in mutated DDR genes in cohort of men with European Ancestry (EA). DDR genes with at least three carriers in CPDR cohort of AA or EA men are tested. A two-sided Fisher Exact Test was performed to assess the p values. Colors of the bars indicate Fisher Exact Test P values of AA vs. EA comparison. Dark blue: P < 0.05; Light blue: 0.05 < P < 0.1; Green: P > 0.1; Gray: not tested. Germline mutations in RAD51 and PMS2 genes are enriched in African American cohort as compared to EA men with P values of 0.0063 and 0.0271 respectively. Germline mutations in FANCA gene is enriched in EA men (Fisher P value is 0.0075). Genes were sorted by carrier rate in AA cohort. Source data are provided as a Source Data file.

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