Fig. 3: Gene Based Total Frequency of DDRG Germline Mutations Compared to Relevant Control Database. | Nature Communications

Fig. 3: Gene Based Total Frequency of DDRG Germline Mutations Compared to Relevant Control Database.

From: Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes

Fig. 3: Gene Based Total Frequency of DDRG Germline Mutations Compared to Relevant Control Database.

Gene based total frequency tests were performed using germline mutants on DDR genes. Two-sided Fisher’s exact tests were conducted using two by two table of number of carriers and non-carriers in this cohort and corresponding cohort in ExACnonTCGA. DDR genes with at least three carriers in CPDR AA or European Ancestry (EA) cohort are tested, (a) Bar plot of total frequency test results by comparing AA cohort and ExACnonTCGA AFR (b) Bar plot of total frequency test results by comparing cohort of EA men and ExACnonTCGA NFE. Colors of the bars indicate Fisher Exact Test P values of case vs. control comparison. Dark blue: P < 0.05; Light blue: 0.05 < P < 0.1; Green: P > 0.1. Source data are provided as a Source Data file.

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