Fig. 4: HR DDRG Pathway based Germline Mutations Profiling in AA and European Ancestry Men. | Nature Communications

Fig. 4: HR DDRG Pathway based Germline Mutations Profiling in AA and European Ancestry Men.

From: Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes

Fig. 4: HR DDRG Pathway based Germline Mutations Profiling in AA and European Ancestry Men.

a Frequency of germline mutations in HR pathway in AA and EA men (b) The pie chart indicates the genes (RAD51, BRCA1, BRCA2, BLM, NBN) harboring 15 HR pathway mutations (c) Patients with variants in HR pathway had developed BCR faster than the patients without HR mutations, when longitudinally followed up after RP (P = 0.022, HR 3.34). The Kaplan–Meier curves were plotted, and log-rank tests were used to assess statistically significant differences between the two curves. Two-sided test was performed to assess the p value. Source data are provided as a Source Data file.

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