Table 1 Clinico-pathologic characteristics and DDRG mutation status of 531 patients with prostate cancer stratified by ancestry.

From: Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes

Ā 

African American (N = 259)

European ancestry (N = 272)

p value

Gleason Grade

Ā Ā 

0.166

ā€ƒ3 + 3

127 (51.6%)

160 (59.9%)

Ā 

ā€ƒ3 + 4

69 (28.0%)

63 (23.6%)

Ā 

ā€ƒ4 + 3/8-10

50 (20.3%)

44 (16.5%)

Ā 

Missing Data

13

5

Ā 

Diagnosis Age (in years)

Ā Ā 

0.078

ā€ƒOld (>55 years)

193 (74.5%)

220 (80.9%)

Ā 

ā€ƒYoung (≤55 years)

66 (25.5%)

52 (19.1%)

Ā 

PSA Category (ng/ml)

Ā Ā 

0.241

ā€ƒ(<4)

59 (23.0%)

81 (29.8%)

Ā 

ā€ƒ(4–9)

164 (63.8%)

165 (60.7%)

Ā 

ā€ƒ(10–20)

26 (10.1%)

19 (7.0%)

Ā 

ā€ƒ(>20)

8 (3.1%)

7 (2.6%)

Ā 

Missing Data

2

0

Ā 

Pathological T Stage

Ā Ā 

0.041

ā€ƒT1a–T2a

6 (2.6%)

17 (6.7%)

Ā 

ā€ƒT2b–T2c

166 (72.2%) 158

158 (62.2%)

Ā 

ā€ƒT3a–T3c

58 (25.2%)

78 (30.7%)

Ā 

ā€ƒT4

0 (0.0%)

2 (0.8%)

Ā 

Missing Data

29

18

Ā 

ā€ƒBCR

Ā Ā 

0.788

ā€ƒNo

203 (86.0%)

224 (85.2%)

Ā 

ā€ƒYes

33 (14.0%)

39 (14.8%)

Ā 

Missing Data

23

9

Ā 

Metastasis

Ā Ā 

0.451

ā€ƒNo

250 (96.5%)

259 (95.2%)

Ā 

ā€ƒYes

9 (3.5%)

13 (4.8%)

Ā 

Any DDRG Mutations

Ā Ā 

0.687

No Mutation

200 (77.2%)

206 (75.7%)

Ā 

Any Mutation

59 (22.8%)

66 (24.3%)

Ā 

Number of DDRG Mutations Per Patient

Ā Ā 

0.170

ā€ƒ0

200 (77.2%)

206 (75.7%)

Ā 

ā€ƒ1

56 (21.6%)

56 (20.6%)

Ā 

ā€ƒ2

3 (1.2%)

10 (3.7%)

Ā 
  1. Two-sided test was performed to assess the p value; P values < 0.05 is considered significant.
  2. PSA Prostate Serum Antigen, BCR Biochemical Recurrence, DDRG DNA Damage Repair Gene.