Fig. 2: L1CAM expression in mature germinal centers of tertiary lymphoid structures.
From: Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
a Representative H&E image of a TLS in EC, which were observed in 29 of the 273 cases of the Uterine Corpus Endometrial Carcinoma (UCEC) cohort of The Cancer Genome Atlas (TCGA) research consortium. b Frequency of molecular subgroups by TLS status in endometrial cancer patients included in the UCEC TCGA. Source data are available at: https://portal.gdc.cancer.gov. c Differential gene expression of TLS-positive versus TLS-negative TCGA UCEC cases. d Representative L1CAM-positive TLS case. Arrows indicate TLS. e Co-immunofluorescent analysis of L1CAM-positive TLS with L1CAM and CD21. The experiment was repeated four times with similar results. n Number of cases, POLEmut Pathogenic polymerase epsilon mutation, MMRd Mismatch repair-deficient, p53abn p53 abnormal, NSMP No specific molecular profile, TLS Tertiary lymphoid structure, L1CAM Ligant-1 cell adhesion molecule, DAPI 4′,6-diamidino-2-phenylindole. Source data are provided as a Source Data File.
