Fig. 4: Conformational change of kinase core relative to the NTD-A of Mcm4. | Nature Communications

Fig. 4: Conformational change of kinase core relative to the NTD-A of Mcm4.

From: Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase

Fig. 4: Conformational change of kinase core relative to the NTD-A of Mcm4.

a Side view of the cryo-EM density map of the DH-DDK complex (State I). b Magnified view of the boxed region in (a), highlighting the kinase core of DDK bound to the NTD-A of Mcm4 via motif C of Dbf4. c Same as (a) but with a 90° rotation and shown in top view with a focus on Mcm4 and DDK. d–f Same as (a–c) but shown in State II of the DH-DDK structure.

Back to article page