Fig. 3: Recognition mechanism of GAL1R and GAL2R by galanin.
From: Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
The overall binding pose of galanin in GAL1R and GAL2R in the side view (a) and extracellular view (b). c Two hydrophobic patches at the extracellular surface of the GAL1R binding pocket sandwich with galanin. Two hydrophobic patches are highlighted as white dashed ovals. Receptor surface is colored by hydrophobicity, from white for hydrophilic to red for hydrophobic. Detailed interactions between galanin and the hydrophobic patch in ECL2 of GAL1R (d) and GAL2R (e). The H-bond is shown as a red dashed line. Detailed interactions between galanin and the hydrophobic patch in TM6-ECL3-TM7 of GAL1R (f) and GAL2R (g). h Interactions between Y9P and residues of two galanin receptors. i Detailed interactions between G1P of galanin and two galanin receptors.
