Fig. 3: Characterization of the 2030 significant metabolite genetic association signals.
From: Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci
Comparison of MAFs for the 1143 index variants between METSIM and non-Finnish Europeans in gnomAD v3.1; index variants are colored a purple if MAF>10-fold greater in METSIM than in non-Finnish Europeans; or b blue if they represent novel association signals. The dashed line is of slope one through the origin. c Overlaid Manhattan plots of the 1391 metabolite GWAS. The red dashed line depicts genome-wide significance threshold P = 7.2 × 10−11. The associations at 40 novel putative causal genes within novel regions (blue) and 18 novel putative causal genes within previously reported regions (maize) are highlighted. The seven novel putative causal genes implicated only by fine-mapping analysis are starred. HADHA/B represents the HADHA and HADHB genes and ARSD/L the ARSD and ARSL genes.
