Fig. 5: CuAAC reaction catalyzed by MApt-Cu30 in specific-type cells for prodrug activation.
From: DNA-based platform for efficient and precisely targeted bioorthogonal catalysis in living systems
a Cytotoxicity of prodrug 4 and 5 on MCF-7 cells. Data were presented as mean ± SD (n = 3 independent experiments). b Cell viability of different cells treated with 4 + 5 + MApt-Cu30. The prodrug was activated and Rsv analogue was synthesized to assess the targeted therapeutic effect. Data were presented as mean ± SD (n = 3 independent experiments). c Flow cytometry analysis of the apoptotic proportion of different cells treated with 4 + 5, WA-Cu30, MApt-Cu30, 4 + 5 + WA-Cu30 and 4 + 5 + MApt-Cu30, respectively. Source data are provided as a Source Data file.
