Fig. 1: Transferrin and IgG N-glycome GWAMA summary Miami plot.
From: Genetic regulation of post-translational modification of two distinct proteins
Miami plot pooling together meta-analysis results obtained across all 35 transferrin glycan traits at the top in orange, and across all 24 IgG glycan traits at the bottom in blue. The pooling was performed by selecting the lowest p value (y-axis) from all 35 (TF) or 24 (IgG) glycan traits for every genomic position (x axis). For transferrin N-glycome associations, '*' marks loci previously reported in total blood plasma N-glycome GWAS22,23,24,25, while '~' marks loci previously reported in IgG N-glycome GWAS26,27,28,29. The Bonferroni-corrected genome-wide significance threshold for the transferrin N-glycome meta-analysis (horizontal red line in the top part of the plot) corresponds to 1.43 × 10−9, while Bonferroni-corrected genome-wide significance threshold for the IgG N-glycome meta-analysis (horizontal red line in the bottom part of the plot) corresponds to 2.08 × 10−9. For simplicity, SNPs with p value > 1 × 10−3 are not plotted. Gene or sets of genes annotated for transferrin N-glycome loci have been prioritised in this study; gene or sets of genes annotated for IgG N-glycome loci are those prioritised by Klarić et al.26. P values are derived from the two-sided Wald test with one degree of freedom.
