Fig. 4: Colocalisation of transferrin and IgG glycosylation traits in the FUT6 locus.
From: Genetic regulation of post-translational modification of two distinct proteins
Local association patterns for A transferrin TfGP32 and B IgG GP20 glycans, and C their colocalisation pattern at the FUT6 locus. TfGP32 and IgG GP20 association patterns do not colocalise, with PP.H3 (posterior probability for hypothesis 3, of different causal variants) of 99.7%. The natural logarithm of Approximate Bayes Factor (ABF) of each SNP for transferrin TfGP32 and IgG GP20 in the FUT6 region shows that TfGP32 and GP20 associations are not concordant (the patterns of ln(ABF) calculated for each SNP of both traits do not overlap), suggesting that two different underlying causal variants in this region regulate glycosylation of these two proteins. SNP most strongly associated in the region with the listed glycan trait is reported in bold and labelled. For comparison, SNP most strongly associated with the other listed glycan trait is reported in italic, in the same panel.
