Fig. 8: Schematic diagram showing the role of AB-EVs as a messenger for calcification paradox by favoring BMSC adipogenesis and VSMC calcification via transferring miR-483-5p and miR-2861.
From: Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox
During bone resorption, AB-EVs secreted by osteocytes are released from bone matrix into bone marrow, where AB-EVs promote PPARγ expression and adipogenic differentiation of BMSCs rather than osteogenesis by delivering miR-483-5p, thus leading to bone-fat imbalance and osteoporosis. AB-EVs are also transported into circulation and deposited in blood vessels to stimulate RUNX2 expression and osteogenic transition of VSMCs via transferring miR-2861, thereby causing vascular calcification.
