Fig. 7: Combined fRIP-seq and RNA-seq datasets uncover the broad effects in gene expression and coregulatory gene networks modulated by KrrA function.
From: An RNA-binding protein acts as a major post-transcriptional modulator in Bacillus anthracis
A The transcript abundance of 73 direct targets was significantly affected by KrrA regulation and these direct RNA targets are grouped into various functional categories. B Combined fRIP-seq and RNA-seq data showing global changes modulated by KrrA function. Each bar represents a gene with significantly differential abundance. Each level of color gradation represents a fivefold change. Genes with ≥15-fold change are represented with bars that hit the maximum limit. The bars in different colors show genes with differential abundance under vehicle (green), ‘205-treated (red), or both conditions (blue). The triangles indicate the KrrA-regulated transcripts that are involved in TCS signaling (black), competence (red), sporulation (green), and germination (blue). C Overview of KrrA targets revealed by comparing the datasets of fRIP-seq and RNA-seq.
