Fig. 5: Coordinated essentiality changes of genes encoding members of the same protein complex or metabolic pathway.
a Genes encoding protein complex components are more likely than other genes to exhibit essentiality polymorphism (P = 1.74 × 10−8, one-tailed chi-squared test). Pie size is proportional to gene number. b Correlations presented in Fig. 4a are greater for pairs of genes encoding components of the same protein complex (n = 643 gene pairs) than those encoding components of different complexes (n = 24,782), those including only one gene encoding a complex component (indicated by one black square and one white square on the x-axis; n = 77,066), and those not encoding complex components (indicated by two white squares on the x-axis; n = 57,970). c Genes encoding metabolic pathway components are more likely than other genes to exhibit essentiality polymorphism (P = 7.07 × 10−6, one-tailed chi-squared test). Pie size is proportional to gene number. d Correlations presented in Fig. 4a are greater for pairs of genes encoding components of the same metabolic pathway (n = 434) than those encoding components of different pathways (n = 5561), those including only one gene encoding a pathway component (n = 50,270), and those not encoding pathway components (n = 104,196). In the box plots of panels b and d, the lower and upper edges of a box represent the first (qu1) and third (qu3) quartiles, respectively, the horizontal line inside the box indicates the median (md), the whiskers extend to the most extreme values inside inner fences, md ± 1.5(qu3 − qu1), and the dots represent values outside the inner fences (outliers). P-values are from two-tailed Wilcoxon rank-sum tests. Source data are provided as a Source Data file.
