Fig. 6: Adipocyte-selective Gq/11 KO mice show deficits in blood glucose and lipid homeostasis.
From: Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice
a Expression levels of Gαq and Gα11 mRNA in different tissues of adipo-Gq/11 KO mice and control littermates (Gαqflox/flox Gα11 − /− mice lacking the adipoq-Cre transgene) (n = 4 per group). Transcript levels were normalized relative to Gαq mRNA levels of control mice (set equal to 1). b, c Body weight (b) and body composition (fat and lean mass as % of body weight) (c) of adipo-Gq/11 KO mice and control littermates (mouse age: 12 weeks; n = 7–12 per group). d, e GTT (d; the panel to the right shows AUC values) and ITT (e) of adipo-Gq/11 KO mice and control littermates. Blood glucose levels were measured after i.p. injection of 2 g/kg glucose after overnight fasting (d) or of 0.75 U/kg insulin after a 4 hr fast (e), respectively (n = 8–13 per group). f–i, Blood glucose (f), and plasma insulin (g), leptin (h), FFA (i), and glycerol (j) levels of adipo-Gq/11 KO and control mice under fasting and fed conditions (n = 7–12 per group). Data are presented as means ± s.e.m. d, e: two-way ANOVA followed by Bonferroni’s post-hoc test; a, f–j: two-tailed Student’s t-test). Source data are provided as a Source data file.
