Fig. 1: Crystal structures of CidAwMel and CidBwMelDUB, and a model of CidBwMelND1-ND2 reveal the molecular basis for CI. | Nature Communications

Fig. 1: Crystal structures of CidAwMel and CidBwMelDUB, and a model of CidBwMelND1-ND2 reveal the molecular basis for CI.

From: Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue

Fig. 1: Crystal structures of CidAwMel and CidBwMelDUB, and a model of CidBwMelND1-ND2 reveal the molecular basis for CI.The alternative text for this image may have been generated using AI.

a CidAwMel and CidBwMel, and CidAwPip and CidBwPip form alternative two-gene CI systems. Each domain is assigned a unique color. b CidAwMel contains mostly α-helices. The C-terminal domain contains six HEAT repeats (HR1-HR6). Residues 111-154 and 158-165 are disordered. c CidBwMelDUB consists of a five-stranded β sheet flanked by α helices on both sides. The active center residues are labeled and shown as balls and sticks. d A model for CidBwMelND1-ND2 was built with AlphaFold. e The crystal structure of the CidAwPip(Tunis)-CidBwPip(Tunis)ND1-ND2 complex. NTD: N-terminal domain; CTD C-terminal domain; ND nuclease domain; DUB deubiquitylase domain; AA amino acids; HR HEAT repeats.

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