Fig. 1: Inspirations towards the development of carbene insertion into α-C–H bonds of ethers using N-sulfonylhydrazones.
From: Silver-catalyzed site-selective C(sp3)−H benzylation of ethers with N-triftosylhydrazones
a α-C−H functionalization of ethers via carbene insertion process: drawbacks and solutions. b This work: Silver-catalyzed α-C–H insertion reactions of ethers with N-triftosylhydrazones for the synthesis of medicinally relevant branched homobenzylic ethers. c Representative drugs demonstrating the ubiquity of branched homobenzylic ether motifs in bioactive molecules. Ar, aryl; Alk, alkyl; Tfs, triftosyl; thf, tetrahydrofuran; Ms, methylsulfonyl.
