Fig. 4: Cross-platform data integration. | Nature Communications

Fig. 4: Cross-platform data integration.

From: cyCombine allows for robust integration of single-cell cytometry datasets within and across technologies

Fig. 4: Cross-platform data integration.The alt text for this image may have been generated using AI.

a UMAP plot for uncorrected dataset consisting of 6776 cells from each of the CITE-seq, mass cytometry (CyTOF), and spectral flow cytometry (SFC) datasets. b UMAP for the cells of a after batch correction with cyCombine. c Density plots for earth mover’s distances (EMD) calculated per marker, per SOM node for each of the pairwise comparisons between platforms. The self-organizing map (SOM) nodes used were those derived from corrected data. d The uncorrected UMAP faceted by technology and colored by manually assigned labels determined on each dataset separately before correction. e Same as in d, but for the corrected UMAP.

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