Fig. 4: Enantioselection in TPPS3 J-aggregate formation: overview of the experimental results.
a Schematic representation of the experimental procedure and of the deterministic enantioselection observed when using Rlong (or Llong) device. Mixing of the reactants, porphyrin protonation and aggregate nucleation occur during the short residence time in-chip (<2 s). Further aggregation and the appearance of CD bands occur overtime off-chip. b Representative CD spectra showing the opposite enantioselection obtained when using Rlong and Llong devices. c Representative CD spectra obtained in the case of the experiments performed with the Linear device (stochastic symmetry breaking). d Left: stacked histogram representing the percentage of positive (blue) and negative (pink) CD couplets obtained when using Llong, Rlong and Linear microfluidic devices. Right: distribution of the peak-to-peak amplitudes for the positive (blue) and negative (pink) CD couplets observed in the same experiments. The centre of the squares indicates the average amplitude, the vertical bars represent the spreading of the amplitude values. e Representative CD spectra obtained in samples prepared with Rshort (black) and Lshort (red) devices showing trisignate bands.
