Table 1 Summary of prodrugs and their activity.
From: CDP-ribitol prodrug treatment ameliorates ISPD-deficient muscular dystrophy mouse model
CDP-Rbo derivatives (simplified abbreviation) | Effective concentration* (μM) |
|---|---|
CDP-Rbo | 500 |
CDP(DiA)-Rbo | N.D. |
CDP-Rbo(TetA) | 200 |
CDP(DiA)-Rbo(TetA) | N.D. |
CDP-Rbo(TetB) | 100 |
CDP(DiA)-Rbo(TetB) | 100–200 |
CDP(DiB)-Rbo(TetB) | 50–100 |
CDP(DiA)-Rbo(TetMOC) | N.D. |
CDP(DiA)-Rbo(TetIB) | 200 |
CDP(DiA)-Rbo(TetA)-PB1 | 10–20 |
CDP(DiA)-Rbo(TetA)-PB2 | 50–200 |
