Fig. 5: Impact of polygenic risk score on positive prediction value of EBV serological test for NPC.

The numbers of seropositive individuals screened (colored gray and red) relative to the numbers of individuals receiving a benefit from the more thorough clinical assessments (colored red) are shown by the PRS subgroups (top 5th percentile, top decile, top quintile, middle three quintiles and bottom quintile of polygenic risk score). PRS polygenic risk score; PPV predictive prediction value.