Fig. 6: Sympathetic innervation of PDX tumors.

a–f Maximal intensity projection of 3D image stacks of PDX tumors derived from two different patients [PDX1 (a–c), PDX2 (d–f)] and immunostained with anti-TH antibody. Segmentation of PDX tumors is shown in red, intratumoral sympathetic fibers in yellow, and extratumoral fibers in white. Images are representative of four mice analyzed. Scale bars = 200 µm (a, b, d, e), and 50 µm (c, f).