Fig. 7: Reduced survival and increased metastatic spread in sympathectomized KIC mice. | Nature Communications

Fig. 7: Reduced survival and increased metastatic spread in sympathectomized KIC mice.

From: Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer

Fig. 7: Reduced survival and increased metastatic spread in sympathectomized KIC mice.The alternative text for this image may have been generated using AI.

a Outline of the experiment. b Kaplan–Meier curve comparing overall survival of control mice treated with 6-OHDA (Ctrl6-OHDA, n = 10) and KIC mice treated with AA (KICAA, n = 12) or 6-OHDA (KIC6-OHDA, n = 8). For KICAA versus KIC6-OHDA: P = 0.0132 (Log-rank test) and hazard ratio B/A = 2.711 (A = KICAA and B = KIC6-OHDA). c–h Representative pictures of livers (c, d), HPS-stained liver sections (e, f), and intestine (g, h) of AA- or 6-OHDA-treated KIC mice collected at autopsy. The arrows point to macrometastases. e, f show representative images of three mice analyzed per treatment group. i–j Pie charts showing the percentage of AA- and 6-OHDA-treated KIC mice without and with liver metastasis (i) and carcinomatosis in the intestine mesentery (j) at death (KICAA, n = 9; KIC6-OHDA, n = 6). Scale bars = 5 mm (c, d and g, h), and 500 µm (e, f). Source data are provided as a Source Data file.

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