Fig. 7: Chromatin accessibility and predicted TF binding in promoter areas of stem cell, cell cycle and calcium flux-related genes of memory CD8+ T cells primed under distinct strengths of TCR and IL-2 signals. | Nature Communications

Fig. 7: Chromatin accessibility and predicted TF binding in promoter areas of stem cell, cell cycle and calcium flux-related genes of memory CD8+ T cells primed under distinct strengths of TCR and IL-2 signals.

From: T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling

Fig. 7

a Heat map shows unique OCRs (yellow) in genes encoding stem cell-related proteins, cell cycle/proliferation and calcium fluxes that were indicated in Fig. 6b when TCR and IL-2 signals were modulated together, in the promoter area and close to the TSS (±~3 kb). Chromatin region status (open, yellow/closed, gray) in WT and Il2ramut/mut OT-I memory cells primed with Lm-N4 or Lm-T4 are reported. b Selected examples of genes (Tcfl2, Dvl2, Cdc16, Cacnac1) with differential OCRs (red box) in these OT-I memory CD8+ T cells. Higher magnifications of the OCRs show FIMO-predicted binding sites for indicated TFs.

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